Open-market purchases and sales reported on SEC Forms 4 and 5, with each filing and its footnotes.
Since Oct 4, 2025
Transactions
47
Purchases
0
Sales
47
Purchase value
$0.00
Sale value
$60.29M
Values are shares multiplied by reported price when both were supplied, each trade counted once however many filers reported it.
Megna Michael RCHIEF ACCOUNTING OFFICER
4Rule 10b5-1 plan disclosed
Filed Sep 3, 2026Period of report Jul 15, 20260001464583-26-000008
Transaction
Security
Shares
Price
ValueValue (shares × price)
Held after
Ownership
SaleSep 3, 2026
Class A Ordinary ShareF3
4,600
$80.30
$369.38K
29,062
Direct
Filing footnotes · 9
F1The reporting person is voluntarily reporting the acquisition of these shares pursuant to the Issuer's 2018 Employee Share Purchase Plan for the purchase period of January 16, 2026 to July 15, 2026. The acquisition of these shares was exempt pursuant to Rule 16b-3(e).
F2Each Restricted Share Unit (RSU) represents a contingent right to receive one Class A Ordinary Share of the Issuer.
F3This transaction was effected pursuant to a 10b5-1 plan executed by the reporting person on May 24, 2025.
F4The RSUs vest over a four-year period, with 25% of the RSUs vesting on each yearly anniversary of the date of grant, September 1, 2026.
F5The option vests and becomes exercisable as to 25% of the total grant on the first anniversary of the vesting commencement date and vests in 36 equal monthly installments thereafter. The vesting commencement date is September 1, 2026.
F6The RSUs vest over a four-year period, with 25% of the RSUs vesting on each yearly anniversary of the date of grant, September 1, 2025.
F7The RSUs vest over a four-year period, with 25% of the RSUs vesting on each yearly anniversary of the grant date, September 1, 2024.
F8The RSUs vest over a four-year period, with 25% of the RSUs vesting on each yearly anniversary of the date of grant, September 1, 2023.
F9The RSUs vest over a four-year period, with 25% of the RSUs vesting on each yearly anniversary of the date of grant, September 1, 2022.
Filed Jul 31, 2026Period of report Jul 29, 20260001337798-26-000004
Transaction
Security
Shares
Price
ValueValue (shares × price)
Held after
Ownership
SaleJul 29, 2026
Class A Ordinary Share
3,673
$81.43
$299.09K
11,672
Direct
Paolini John F.CHIEF MEDICAL OFFICER
4Rule 10b5-1 plan disclosed
Filed May 5, 2026Period of report May 1, 20260001741533-26-000008
Transaction
Security
Shares
Price
ValueValue (shares × price)
Held after
Ownership
Sale
Patel Sanj KDirector · CHAIRMAN & CEO
4Rule 10b5-1 plan disclosed
Filed May 1, 2026Period of report May 1, 20260001532218-26-000008
Transaction
Security
Shares
Price
ValueValue (shares × price)
Held after
Ownership
Sale
Patel Sanj KDirector · CHAIRMAN & CEO
4Rule 10b5-1 plan disclosed
Filed Apr 30, 2026Period of report Apr 28, 20260001532218-26-000006
Transaction
Security
Shares
Price
ValueValue (shares × price)
Held after
Ownership
Sale
Quart Barry DDirector
4Rule 10b5-1 plan disclosed
Filed Apr 29, 2026Period of report Apr 28, 20260001384243-26-000010
Transaction
Security
Shares
Price
ValueValue (shares × price)
Held after
Ownership
Sale
Moat RossCHIEF OPERATING OFFICER
4Rule 10b5-1 plan disclosed
Filed Apr 13, 2026Period of report Apr 9, 20260001857177-26-000006
Transaction
Security
Shares
Price
ValueValue (shares × price)
Held after
Ownership
Sale
Megna Michael RCHIEF ACCOUNTING OFFICER
4Rule 10b5-1 plan disclosed
Filed Apr 13, 2026Period of report Apr 9, 20260001464583-26-000006
Transaction
Security
Shares
Price
ValueValue (shares × price)
Held after
Ownership
Sale
Moat RossCHIEF OPERATING OFFICER
4Rule 10b5-1 plan disclosed
Filed Apr 8, 2026Period of report Apr 6, 20260001857177-26-000004
Transaction
Security
Shares
Price
ValueValue (shares × price)
Held after
Ownership
Sale
Patel Sanj KDirector · CHAIRMAN & CEO
4Rule 10b5-1 plan disclosed
Filed Apr 8, 2026Period of report Apr 6, 20260001532218-26-000004
Transaction
Security
Shares
Price
ValueValue (shares × price)
Held after
Ownership
Sale
Quart Barry DDirector
4Rule 10b5-1 plan disclosed
Filed Apr 8, 2026Period of report Apr 6, 20260001384243-26-000008
Transaction
Security
Shares
Price
ValueValue (shares × price)
Held after
Ownership
Sale
Ragosa MarkCHIEF FINANCIAL OFFICER
4Rule 10b5-1 plan disclosed
Filed Mar 11, 2026Period of report Mar 9, 20260001835458-26-000006
Transaction
Security
Shares
Price
ValueValue (shares × price)
Held after
Ownership
Sale
Paolini John F.CHIEF MEDICAL OFFICER
4Rule 10b5-1 plan disclosed
Filed Mar 4, 2026Period of report Mar 2, 20260001741533-26-000002
Transaction
Security
Shares
Price
ValueValue (shares × price)
Held after
Ownership
Sale
Quart Barry DDirector
4Rule 10b5-1 plan disclosed
Filed Feb 12, 2026Period of report Feb 10, 20260001384243-26-000004
Transaction
Security
Shares
Price
ValueValue (shares × price)
Held after
Ownership
Sale
Ragosa MarkCHIEF FINANCIAL OFFICER
4Rule 10b5-1 plan disclosed
Filed Feb 11, 2026Period of report Feb 9, 20260001835458-26-000004
Transaction
Security
Shares
Price
ValueValue (shares × price)
Held after
Ownership
Sale
Quart Barry DDirector
4Rule 10b5-1 plan disclosed
Filed Feb 4, 2026Period of report Feb 2, 20260001384243-26-000002
Transaction
Security
Shares
Price
ValueValue (shares × price)
Held after
Ownership
Sale
Ragosa MarkCHIEF FINANCIAL OFFICER
4Rule 10b5-1 plan disclosed
Filed Jan 9, 2026Period of report Jan 8, 20260001835458-26-000002
Transaction
Security
Shares
Price
ValueValue (shares × price)
Held after
Ownership
Sale
Tessari EbenCHIEF OPERATING OFFICER
4Rule 10b5-1 plan disclosed
Filed Dec 17, 2025Period of report Dec 15, 20250001867899-25-000013
Transaction
Security
Shares
Price
ValueValue (shares × price)
Held after
Ownership
Sale
Quart Barry DDirector
4Rule 10b5-1 plan disclosed
Filed Dec 17, 2025Period of report Dec 15, 20250001384243-25-000004
Transaction
Security
Shares
Price
ValueValue (shares × price)
Held after
Ownership
Sale
Ragosa MarkCHIEF FINANCIAL OFFICER
4Rule 10b5-1 plan disclosed
Filed Dec 10, 2025Period of report Dec 8, 20250001835458-25-000007
Transaction
Security
Shares
Price
ValueValue (shares × price)
Held after
Ownership
Sale
Tessari EbenCHIEF OPERATING OFFICER
4Rule 10b5-1 plan disclosed
Filed Dec 1, 2025Period of report Nov 26, 20250001867899-25-000011
Transaction
Security
Shares
Price
ValueValue (shares × price)
Held after
Ownership
Sale
Tessari EbenCHIEF OPERATING OFFICER
4Rule 10b5-1 plan disclosed
Filed Nov 19, 2025Period of report Nov 17, 20250001867899-25-000009
Transaction
Security
Shares
Price
ValueValue (shares × price)
Held after
Ownership
Sale
Ragosa MarkCHIEF FINANCIAL OFFICER
4Rule 10b5-1 plan disclosed
Filed Nov 14, 2025Period of report Nov 12, 20250001835458-25-000005
Transaction
Security
Shares
Price
ValueValue (shares × price)
Held after
Ownership
Sale
Paolini John F.CHIEF MEDICAL OFFICER
4Rule 10b5-1 plan disclosed
Filed Nov 4, 2025Period of report Oct 31, 20250001741533-25-000003
Transaction
Security
Shares
Price
ValueValue (shares × price)
Held after
Ownership
Sale
Ragosa MarkCHIEF FINANCIAL OFFICER
4Rule 10b5-1 plan disclosed
Filed Oct 30, 2025Period of report Oct 28, 20250001835458-25-000003
Transaction
Security
Shares
Price
ValueValue (shares × price)
Held after
Ownership
Sale
Patel Sanj KDirector · CHAIRMAN & CEO
4Rule 10b5-1 plan disclosed
Filed Oct 22, 2025Period of report Oct 20, 20250001532218-25-000005
Transaction
Security
Shares
Price
ValueValue (shares × price)
Held after
Ownership
Sale
Megna Michael RCHIEF ACCOUNTING OFFICER
4Rule 10b5-1 plan disclosed
Filed Oct 22, 2025Period of report Oct 20, 20250001464583-25-000005
Transaction
Security
Shares
Price
ValueValue (shares × price)
Held after
Ownership
Sale
Tessari EbenCHIEF OPERATING OFFICER
4Rule 10b5-1 plan disclosed
Filed Oct 16, 2025Period of report Oct 14, 20250001867899-25-000007
Transaction
Security
Shares
Price
ValueValue (shares × price)
Held after
Ownership
Sale
P and S transaction codes only. Grants, gifts, option exercises, tax withholding, and Form 144 notices are not counted as purchases or sales. A row whose filed price fails a plausibility check, or that is not common stock, is listed but left out of the values; a trade reported by several filers is counted once.
Filing footnotes · 1
F1This transaction involves a bona fide gift of securities from the reporting person to a donor advised fund.
F1This transaction was effected pursuant to a Rule 10b5-1 plan executed by the reporting person on November 18, 2025.
F2This transaction was executed in multiple trades through a broker-dealer at prices ranging between $52.765 and $53.76. The price reported in this column reflects a weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.
F3This transaction was executed in multiple trades through a broker-dealer at prices ranging between $53.765 and $54.22. The price reported in this column reflects a weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.
F1This transaction was effected pursuant to a 10b5-1 plan executed by the reporting person on October 31, 2025.
F2This transaction was executed in multiple trades through a broker-dealer at prices ranging between $54.00 and $54.155. The price reported in this column reflects a weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.
F1This transaction was effected pursuant to a 10b5-1 plan executed by the reporting person on October 31, 2025.
F2This transaction was executed in multiple trades through a broker-dealer at prices ranging between $50.00 and $50.985. The price reported in this column reflects a weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.
F3This transaction was executed in multiple trades through a broker-dealer at prices ranging between $51.00 and $51.99. The price reported in this column reflects a weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.
F4This transaction was executed in multiple trades through a broker-dealer at prices ranging between $52.00 and $52.58. The price reported in this column reflects a weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.
F5This transaction was executed in multiple trades through a broker-dealer at prices ranging between $54.00 and $54.22. The price reported in this column reflects a weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.
F6This transaction was executed in multiple trades through a broker-dealer at prices ranging between $54.00 and $54.225. The price reported in this column reflects a weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.
F7This transaction was executed in multiple trades through a broker-dealer at prices ranging between $54.00 and $54.03. The price reported in this column reflects a weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.
F1This transaction was effected pursuant to a 10b5-1 plan executed by the reporting person on September 11, 2025.
F2This transaction was executed in multiple trades through a broker-dealer at prices ranging between $50.00 and $50.725. The price reported in this column reflects a weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.
F1This transaction was effected pursuant to a 10b5-1 plan executed by the reporting person on October 31, 2025.
F2This transaction was executed in multiple trades through a broker-dealer at prices ranging between $50.005 and $50.03. The price reported in this column reflects a weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.
F3Each Restricted Share Unit (RSU) represents a contingent right to receive one Class A Ordinary Share of the Issuer.
F4The option is fully vested and exercisable.
F5The RSUs vest over a four-year period, with 25% of the RSs vesting on the yearly anniversary of the grant date, April 7, 2022.
F1This transaction was effected pursuant to a 10b5-1 plan executed by the reporting person on September 11, 2025.
F2This transaction was executed in multiple trades through a broker-dealer at prices ranging between $50.00 and $50.015. The price reported in this column reflects a weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.
F1This transaction was effected pursuant to a 10b5-1 plan executed by the reporting person on August 14, 2025.
F2This transaction was executed in multiple trades through a broker-dealer at prices ranging between $44.885 and $45.88. The price reported in this column reflects a weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.
F3This transaction was executed in multiple trades through a broker-dealer at prices ranging between $45.89 and $46.79. The price reported in this column reflects a weighted average sales price. Upon request, the reporting person will provide to the SEC staff fullinformation regarding the number of Shares sold at each price.
F4The option is fully vested and exercisable.
F5The option vests and becomes exercisable as to 25% of the total grant on the first anniversary of the vesting commencement date and vests in 36 equal monthly installments thereafter. The vesting commencement date is September 1, 2023.
F6The option vests and becomes exercisable as to 25% of the total grant on the first anniversary of the vesting commencement date and vests in 36 equal monthly installments thereafter. The vesting commencement date is April 1, 2024.
F7The option vests and becomes exercisable as to 25% of the total grant on the first anniversary of the vesting commencement date and vests in 36 equal monthly installments thereafter. The vesting commencement date is September 1, 2024.
F1This transaction was effected pursuant to a Rule 10b5-1 plan executed by the reporting person on November 18, 2025.
F2This transaction was executed in multiple trades through a broker-dealer at prices ranging between $43.555 and $44.55. The price reported in this column reflects a weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.
F3This transaction was executed in multiple trades through a broker-dealer at prices ranging between $44.555 and $45.49. The price reported in this column reflects a weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.
F4This transaction was executed in multiple trades through a broker-dealer at prices ranging between $45.56 and $46.09. The price reported in this column reflects a weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.
F1This transaction was effected pursuant to a 10b5-1 plan executed by the reporting person on August 14, 2025.
F2This transaction was executed in multiple trades through a broker-dealer at prices ranging between $42.35 and $43.345. The price reported in this column reflects a weighted average sales price. Upon request, the reporting person will provide to the SEC staff fullinformation regarding the number of Shares sold at each price.
F3This transaction was executed in multiple trades through a broker-dealer at prices ranging between $43.35 and $44.18. The price reported in this column reflects a weighted average sales price. Upon request, the reporting person will provide to the SEC staff fullinformation regarding the number of Shares sold at each price.
F1This transaction was effected pursuant to a 10b5-1 plan executed by the reporting person on September 11, 2025.
F2This transaction was executed in multiple trades through a broker-dealer at prices ranging between $45.00 and $45.02. The price reported in this column reflects a weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.
F3This transaction was executed in multiple trades through a broker-dealer at prices ranging between $45.00 and $45.48. The price reported in this column reflects a weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.
F4This transaction was executed in multiple trades through a broker-dealer at prices ranging between $45.00 and $45.05. The price reported in this column reflects a weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.
F1This transaction was effected pursuant to a 10b5-1 plan executed by the reporting person on August 14, 2025.
F2This transaction was executed in multiple trades through a broker-dealer at prices ranging between $41.44 and $42.24. The price reported in this column reflects a weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.
F1This transaction was effected pursuant to a 10b5-1 plan executed by the reporting person on April 29, 2024.
F2This transaction was executed in multiple trades through a broker-dealer at prices ranging between $41.235 and $41.78. The price reported in this column reflects a weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.
F1This transaction was effected pursuant to a 10b5-1 plan executed by the reporting person on September 11, 2025.
F2This transaction was executed in multiple trades through a broker-dealer at prices ranging between $41.19 and $41.78. The price reported in this column reflects a weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.
F1This transaction was effected pursuant to a 10b5-1 plan executed by the reporting person on August 14, 2025.
F2This transaction was executed in multiple trades through a broker-dealer at prices ranging between $41.20 and $42.08. The price reported in this column reflects a weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.
F3The option vests and becomes exercisable as to 25% of the total grant on the first anniversary of the vesting commencement date and vests in 36 equal monthly installments thereafter. The vesting commencement date is April 7, 2022.
F4The option vests and becomes exercisable as to 25% of the total grant on the first anniversary of the vesting commencement date and vests in 36 equal monthly installments thereafter. The vesting commencement date is September 1, 2022.
F5The option vests and becomes exercisable as to 25% of the total grant on the first anniversary of the vesting commencement date and vests in 36 equal monthly installments thereafter. The vesting commencement date is April 1, 2023.
F1This transaction was effected pursuant to a 10b5-1 plan executed by the reporting person on April 29, 2024.
F2This transaction was executed in multiple trades through a broker-dealer at prices ranging between $39.61 and $40.585. The price reported in this column reflects a weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.
F3This transaction was executed in multiple trades through a broker-dealer at prices ranging between $40.61 and $41.60. The price reported in this column reflects a weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.
F1This transaction was effected pursuant to a 10b5-1 plan executed by the reporting person on September 3, 2024.
F2This transaction was executed in multiple trades through a broker-dealer at prices ranging between $40.93 and $41.035. The price reported in this column reflects a weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.
F1This transaction was effected pursuant to a Rule 10b5-1 plan executed by the reporting person on July 30, 2025.
F2This transaction was executed in multiple trades through a broker-dealer at prices ranging between $36.80 and $37.675. The price reported in this column reflects a weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.
F1This transaction was effected pursuant to a 10b5-1 plan executed by the reporting person on May 7, 2025.
F2This transaction was executed in multiple trades through a broker-dealer at prices ranging between $38.14 and $39.135. The price reported in this column reflects a weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.
F3This transaction was executed in multiple trades through a broker-dealer at prices ranging between $39.14 and $39.55. The price reported in this column reflects a weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.
F4This transaction was executed in multiple trades through a broker-dealer at prices ranging between $38.49 and $39.235. The price reported in this column reflects a weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.
F5This transaction was executed in multiple trades through a broker-dealer at prices ranging between $38.495 and $39.255. The price reported in this column reflects a weighted sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.
F1This transaction was effected pursuant to a 10b5-1 plan executed by the reporting person on May 24, 2025.
F2This transaction was executed in multiple trades through a broker-dealer at prices ranging between $38.14 and $39.135. The price reported in this column reflects a weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.
F3This transaction was executed in multiple trades through a broker-dealer at prices ranging between $39.145 and $39.57. The price reported in this column reflects a weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.
F1This transaction was effected pursuant to a 10b5-1 plan executed by the reporting person on April 29, 2024.
F2This transaction was executed in multiple trades through a broker-dealer at prices ranging between $36.98 and $37.97. The price reported in this column reflects a weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.
F3This transaction was executed in multiple trades through a broker-dealer at prices ranging between $37.98 and $38.00. The price reported in this column reflects a weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.
