What Siren, L.L.C. reported holding on Form 13F for the quarter ended Jun 30, 2026.
CIK 2005245 · Filed Aug 13, 2026
Values are as the managers reported them, in dollars.Open the Form 13F on SEC EDGAR
| 2.9M |
| −7.9% |
| $336.7M |
| 6.8% |
ERASErasca, Inc. | 11.4M | +1.4% | $208.8M | 4.2% |
MANEVeradermics, Inc | 1.7M | +10.0% | $203.5M | 4.1% |
TNGXTango Therapeutics, Inc. | 6.2M | +9.2% | $193.2M | 3.9% |
RVMDRevolution Medicines, Inc. | 900K | −19.0% | $168.6M | 3.4% |
BCAXBicara Therapeutics Inc. | 5.6M | −3.4% | $166.4M | 3.4% |
ARWRArrowhead Pharmaceuticals, Inc. | 1.7M | +6.2% | $139.8M | 2.8% |
ONCBeOne Medicines Ltd. | 465K | ±0% | $132.5M | 2.7% |
EWTXEdgewise Therapeutics, Inc. | 3.2M | −28.1% | $129.4M | 2.6% |
RYTMRhythm Pharmaceuticals, Inc. | 1.1M | +56.6% | $126.2M | 2.6% |
LXRXLexicon Pharmaceuticals, Inc. | 44.3M | ±0% | $106.3M | 2.2% |
ELVNEnliven Therapeutics, Inc. | 1.8M | +137.8% | $90.1M | 1.8% |
SYRESpyre Therapeutics, Inc. | 968.6K | +18.3% | $86M | 1.7% |
PBLSParabilis Medicines, Inc. | 3M | New | $81.9M | 1.7% |
XENEXenon Pharmaceuticals Inc. | 1.3M | ±0% | $79.6M | 1.6% |
SLDBSolid Biosciences Inc. | 7.7M | ±0% | $76.8M | 1.6% |
ABVXAbivax S.A. | 576K | New | $76.8M | 1.6% |
COAGHemab Therapeutics Holdings, Inc. | 2.1M | New | $76.6M | 1.6% |
RCUSArcus Biosciences, Inc. | 2.4M | −19.5% | $74.6M | 1.5% |
COGTCogent Biosciences, Inc. | 1.9M | +8.8% | $72M | 1.5% |
RLAYRelay Therapeutics, Inc. | 3.7M | New | $68.3M | 1.4% |
TSHATaysha Gene Therapies, Inc. | 9.8M | +11.5% | $67.1M | 1.4% |
DFTXDefinium Therapeutics, Inc. | 1.4M | +54.4% | $66.8M | 1.4% |
STOKStoke Therapeutics, Inc. | 2M | ±0% | $65.3M | 1.3% |
IRONDisc Medicine, Inc. | 888.4K | −10.1% | $65M | 1.3% |
CYTKCytokinetics Inc | 759K | +23.6% | $64.7M | 1.3% |
SEPNSepterna, Inc. | 1.9M | −5.0% | $63.6M | 1.3% |
OLMAOlema Pharmaceuticals, Inc. | 4.9M | +2.1% | $60.8M | 1.2% |
CRNXCrinetics Pharmaceuticals, Inc. | 1.4M | −25.4% | $53.2M | 1.1% |
KLRAKailera Therapeutics, Inc. | 2.2M | New | $48.8M | 1% |
DYNDyne Therapeutics, Inc. | 2.1M | −4.5% | $47.3M | 1% |
GPCRStructure Therapeutics Inc. | 873K | −34.3% | $46.9M | 0.9% |
TBLATaboola.com Ltd. | 8.4M | −15.5% | $42.1M | 0.9% |
PVLAPalvella Therapeutics, Inc. | 257.5K | ±0% | $39.3M | 0.8% |
SLNSilence Therapeutics plc | 3.3M | +13.7% | $36.4M | 0.7% |
DNLIDenali Therapeutics Inc. | 1.4M | ±0% | $35.9M | 0.7% |
RELYRemitly Global, Inc. | 1.5M | ±0% | $34.6M | 0.7% |
CGEMCullinan Therapeutics, Inc. | 1.9M | +58.7% | $34.5M | 0.7% |
COFCapital One Financial Corp | 171.6K | New | $34.4M | 0.7% |
TRVITrevi Therapeutics, Inc. | 1.8M | ±0% | $33.3M | 0.7% |
ORICOric Pharmaceuticals, Inc. | 3M | ±0% | $32.5M | 0.7% |
GOOGLAlphabet Inc. | 90K | +37.0% | $32.2M | 0.7% |
DBVTDBV Technologies S.A. | 1.9M | ±0% | $30.5M | 0.6% |
ABSIAbsci Corp | 2.5M | +37.5% | $28.7M | 0.6% |
SIONSionna Therapeutics, Inc. | 610.5K | +103.5% | $26.9M | 0.5% |
RAPPRapport Therapeutics, Inc. | 641.5K | ±0% | $26.7M | 0.5% |
AMLXAmylyx Pharmaceuticals, Inc. | 1.5M | +20.4% | $26.6M | 0.5% |
ANNXAnnexon, Inc. | 4.5M | +12.6% | $25.5M | 0.5% |
MNPRMonopar Therapeutics | 270.1K | ±0% | $25M | 0.5% |
ORKAOruka Therapeutics, Inc. | 250K | New | $23.8M | 0.5% |
SPTXSeaport Therapeutics, Inc. | 1.1M | New | $23.8M | 0.5% |
DMRADamora Therapeutics, Inc. | 900K | ±0% | $23.4M | 0.5% |
TYRATyra Biosciences, Inc. | 725K | New | $23.2M | 0.5% |
ZURAZura Bio Ltd | 3.7M | ±0% | $22M | 0.4% |
TSMTaiwan Semiconductor Manufacturing Co Ltd | 44.7K | +5.9% | $21.3M | 0.4% |
NVDANVIDIA Corp | 95K | +6.6% | $19M | 0.4% |
RZLTRezolute, Inc. | 3.3M | ±0% | $17.3M | 0.4% |
MPLTMapLight Therapeutics, Inc. | 450K | ±0% | $16.1M | 0.3% |
NMRANeumora Therapeutics, Inc. | 8.5M | ±0% | $14.4M | 0.3% |
NBISNebius Group N.V. | 52K | −54.2% | $14.4M | 0.3% |
MSFTMicrosoft Corp | 37.5K | −9.4% | $14M | 0.3% |
CTMXCytomX Therapeutics, Inc. | 3.5M | ±0% | $13M | 0.3% |
GENBGenerate Biomedicines, Inc. | 736.1K | ±0% | $12.4M | 0.3% |
IKTInhibikase Therapeutics, Inc. | 5.9M | ±0% | $11.9M | 0.2% |
ADAGAdagene Inc. | 2.7M | New | $11.2M | 0.2% |
ENGNenGene Therapeutics Inc. | 6.3M | New | $10.8M | 0.2% |
WHWKWhitehawk Therapeutics, Inc. | 2.3M | +12.3% | $10.7M | 0.2% |
DDOGDatadog, Inc. | 40K | −26.3% | $10.4M | 0.2% |
NOWServiceNow, Inc. | 100K | +14.8% | $9.9M | 0.2% |
AVGOBroadcom Inc. | 25K | +66.7% | $9.4M | 0.2% |
IONQIonQ, Inc. | 170K | ±0% | $9.1M | 0.2% |
| 24K | New | $9M | 0.2% |
FROGJFrog Ltd | 95.5K | −25.9% | $8.7M | 0.2% |
OCSOculis Holding AG | 625K | New | $8.7M | 0.2% |
IRENIREN Ltd | 175K | +306.0% | $8M | 0.2% |
AMZNAmazon Com Inc | 32.5K | −30.3% | $7.7M | 0.2% |
CRWDCrowdStrike Holdings, Inc. | 10K | −56.7% | $7.6M | 0.2% |
DSGNDesign Therapeutics, Inc. | 523.2K | New | $7.6M | 0.2% |
PDDPDD Holdings Inc. | 95K | +13.9% | $7.2M | 0.1% |
MSLESatellos Bioscience Inc. | 892.1K | ±0% | $6.9M | 0.1% |
DTDynatrace, Inc. | 155K | +3.3% | $6.8M | 0.1% |
| 23K | New | $6.7M | 0.1% |
TENXTenax Therapeutics, Inc. | 427.1K | ±0% | $6.2M | 0.1% |
VTVTvTv Therapeutics Inc. | 163K | ±0% | $6.1M | 0.1% |
ELOXEloxx Pharmaceuticals, Inc. | 400K | New | $5.6M | 0.1% |
AGMBAgomAb Therapeutics NV | 411.3K | ±0% | $5.3M | 0.1% |
BABAAlibaba Group Holding Ltd | 50K | New | $4.8M | 0.1% |
KRROKorro Bio, Inc. | 347.7K | ±0% | $4.6M | 0.1% |
CLBTCellebrite DI Ltd. | 311.5K | ±0% | $4.5M | 0.1% |
IVVDInvivyd, Inc. | 5M | +25.0% | $4.4M | 0.1% |
OUSTOuster, Inc. | 67.5K | New | $4.2M | 0.1% |
PALIPalisade Bio, Inc. | 2M | New | $4.2M | 0.1% |
AEVAAeva Technologies, Inc. | 145.5K | +32.2% | $4.2M | 0.1% |
SEERSeer, Inc. | 2.5M | ±0% | $4.1M | 0.1% |
NBPNovaBridge Biosciences | 2M | −33.2% | $3.9M | 0.1% |
GTLBGitlab Inc. | 125K | +25.0% | $3.8M | 0.1% |
ODTXOdyssey Therapeutics, Inc. | 200K | New | $3.7M | 0.1% |
FHTXFoghorn Therapeutics Inc. | 720.7K | ±0% | $3.5M | 0.1% |
AGENAgenus Inc | 1.1M | ±0% | $3.3M | 0.1% |
MNDYmonday.com Ltd. | 42.5K | +70.0% | $3.1M | 0.1% |
ZTSZoetis Inc. | 35K | New | $2.5M | 0.1% |
WKWorkiva Inc | 45K | −51.4% | $2.2M | 0.1% |
NFLXNetflix Inc | 25K | New | $1.8M | 0.1% |
KLRSKalaris Therapeutics, Inc. | 435.8K | ±0% | $1.8M | 0.1% |
QNTQuantinuum Inc. | 20K | New | $1.6M | 0.1% |
RANIRani Therapeutics Holdings, Inc. | 2M | ±0% | $1.5M | 0.1% |
TSLATesla, Inc. | 3.5K | −83.7% | $1.5M | 0.1% |
BEKEKE Holdings Inc. | 100K | ±0% | $1.5M | 0.1% |
ENTXEntera Bio Ltd. | 736.5K | New | $1.3M | 0.1% |
MDLNMedline Inc. | 25K | ±0% | $986K | 0.1% |
LITELumentum Holdings Inc. | 1.1K | New | $905.3K | 0.1% |
FIGFigma, Inc. | 50K | ±0% | $904.5K | 0.1% |
GOSSGossamer Bio, Inc. | 5.2M | ±0% | $857.4K | 0.1% |
FOXAFox Corp | 10K | New | $521.6K | 0.1% |
TAT&T Inc. | 25K | New | $517.5K | 0.1% |
NUNu Holdings Ltd. | 25K | ±0% | $334K | 0.1% |
