Open-market purchases and sales reported on SEC Forms 4 and 5, with each filing and its footnotes.
Since Oct 6, 2025
Transactions
30
Purchases
2
Sales
28
Purchase value
$12.50M
Sale value
$604.59K
Values are shares multiplied by reported price when both were supplied, each trade counted once however many filers reported it.
Shook DavidChief Medical Officer
4
Filed Sep 10, 2026Period of report Sep 10, 20260001959742-26-000003
Transaction
Security
Shares
Price
ValueValue (shares × price)
Held after
Ownership
SaleSep 10, 2026
Common StockF1F2
500
$12.70
$6.35K
20,423
Direct
Filing footnotes · 2
F1Shares automatically sold to cover tax withholding obligation from settlement of vested restricted stock units.
F2The price reported above reflects the weighted average price of the shares sold. The sale price ranged from $12.32 to $12.70 per share. Upon request from the SEC staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price within the range set forth in this Form 4.
Filed Jul 17, 2026Period of report Jul 16, 20260001140361-26-028846
Transaction
Security
Shares
Price
ValueValue (shares × price)
Held after
Ownership
Sale
Shook DavidChief Medical Officer
4
Filed Jun 11, 2026Period of report Jun 10, 20260001959742-26-000002
Transaction
Security
Shares
Price
ValueValue (shares × price)
Held after
Ownership
SaleJun 10, 2026
Common StockF1F2
1,977
$12.64
$24.99K
20,923
Bulis Veronica SanchezVP, Corporate Controller
4
Filed Jun 15, 2026Period of report May 11, 20260002095702-26-000004
Transaction
Security
Shares
Price
ValueValue (shares × price)
Held after
Ownership
SaleMay 11, 2026
Common StockF1F2
217
$18.91
$4.10K
15,420
Lee Gary K.Chief Scientific Officer
4
Filed Jun 15, 2026Period of report May 11, 20260001907345-26-000003
Transaction
Security
Shares
Price
ValueValue (shares × price)
Held after
Ownership
SaleMay 11, 2026
Common StockF1F2F3
130
$18.92
$2.46K
Hill Stephen J.Chief Operating Officer
4
Filed Jun 15, 2026Period of report May 11, 20260001866154-26-000003
Transaction
Security
Shares
Price
ValueValue (shares × price)
Held after
Ownership
SaleMay 11, 2026
Common StockF1F2F3
89
$18.92
$1.68K
Seely LynnDirector · President and CEO
4
Filed Jun 15, 2026Period of report May 11, 20260001327111-26-000003
Transaction
Security
Shares
Price
ValueValue (shares × price)
Held after
Ownership
SaleMay 11, 2026
Common StockF1F2
388
$18.91
$7.34K
73,878
ARCH Venture Fund IX, L.P.10% owner
ARCH Venture Fund IX Overage, L.P.10% owner
ARCH Venture Partners IX, LLC10% owner
ARCH Venture Partners IX, L.P.10% owner
ARCH Venture Partners IX Overage, L.P.10% owner
4
Filed Mar 9, 2026Period of report Mar 6, 20260001012975-26-000235
Transaction
Security
Shares
Price
ValueValue (shares × price)
Held after
Ownership
Purchase
ARCH Venture Fund XIII, L.P.10% owner
ARCH Venture Partners XIII, LLC10% owner
ARCH Venture Partners XIII, L.P.10% owner
Berns Paul L10% owner
Burow Kristina10% owner
Bybee Clinton10% owner
Crandell Keith10% owner
Gillis Steven10% owner
Nelsen Robert10% owner
4
Filed Mar 9, 2026Period of report Mar 6, 20260001012975-26-000234
Transaction
Security
Shares
Price
ValueValue (shares × price)
Lee Gary K.Chief Scientific Officer
4
Filed Feb 12, 2026Period of report Feb 11, 20260001907345-26-000002
Transaction
Security
Shares
Price
ValueValue (shares × price)
Held after
Ownership
SaleFeb 11, 2026
Common StockF1F2
1,671
$23.39
$39.08K
16,938
Hill Stephen J.Chief Operating Officer
4
Filed Feb 12, 2026Period of report Feb 11, 20260001866154-26-000002
Transaction
Security
Shares
Price
ValueValue (shares × price)
Held after
Ownership
SaleFeb 11, 2026
Common StockF1F2
1,236
$23.39
$28.91K
17,795
Seely LynnDirector · President and CEO
4
Filed Feb 12, 2026Period of report Feb 11, 20260001327111-26-000002
Transaction
Security
Shares
Price
ValueValue (shares × price)
Held after
Ownership
SaleFeb 11, 2026
Common StockF1F2
7,455
$23.39
$174.37K
74,266
Bulis Veronica SanchezVP, Corporate Controller
4
Filed Feb 11, 2026Period of report Feb 10, 20260002095702-26-000002
Transaction
Security
Shares
Price
ValueValue (shares × price)
Held after
Ownership
SaleFeb 10, 2026
Common StockF2
254
$23.12
$5.87K
15,637
Direct
Lee Gary K.Chief Scientific Officer
4
Filed Feb 11, 2026Period of report Feb 9, 20260001907345-26-000001
Transaction
Security
Shares
Price
ValueValue (shares × price)
Held after
Ownership
SaleFeb 10, 2026
Common StockF3
147
$23.12
$3.40K
18,609
Direct
Hill Stephen J.Chief Operating Officer
4
Filed Feb 11, 2026Period of report Feb 9, 20260001866154-26-000001
Transaction
Security
Shares
Price
ValueValue (shares × price)
Held after
Ownership
SaleFeb 10, 2026
Common StockF3
109
$23.12
$2.52K
19,031
Direct
Seely LynnDirector · President and CEO
4
Filed Feb 11, 2026Period of report Feb 9, 20260001327111-26-000001
Transaction
Security
Shares
Price
ValueValue (shares × price)
Held after
Ownership
SaleFeb 10, 2026
Common StockF2
438
$23.12
$10.13K
81,721
Direct
Bulis Veronica SanchezVP, Corporate Controller
4
Filed Jan 6, 2026Period of report Dec 24, 20250002095702-26-000001
Transaction
Security
Shares
Price
ValueValue (shares × price)
Held after
Ownership
SaleDec 30, 2025
Common Stock
936
$32.32
$30.25K
7,141
Direct
Bulis Veronica SanchezVP, Corporate Controller
4
Filed Nov 12, 2025Period of report Nov 10, 20250002095702-25-000003
Transaction
Security
Shares
Price
ValueValue (shares × price)
Held after
Ownership
SaleNov 10, 2025
Common StockF1F2
239
$16.10
$3.85K
9,213
Lee Gary K.Chief Scientific Officer
4
Filed Nov 12, 2025Period of report Nov 10, 20250001907345-25-000006
Transaction
Security
Shares
Price
ValueValue (shares × price)
Held after
Ownership
SaleNov 10, 2025
Common StockF1
138
$16.16
$2.23K
15,366
Direct
Hill Stephen J.Chief Operating Officer
4
Filed Nov 12, 2025Period of report Nov 10, 20250001866154-25-000006
Transaction
Security
Shares
Price
ValueValue (shares × price)
Held after
Ownership
SaleNov 10, 2025
Common StockF1
95
$16.12
$1.53K
15,750
Direct
Seely LynnDirector · President and CEO
4
Filed Nov 12, 2025Period of report Nov 10, 20250001327111-25-000007
Transaction
Security
Shares
Price
ValueValue (shares × price)
Held after
Ownership
SaleNov 10, 2025
Common StockF1
412
$16.11
$6.64K
67,159
Direct
P and S transaction codes only. Grants, gifts, option exercises, tax withholding, and Form 144 notices are not counted as purchases or sales. A row whose filed price fails a plausibility check, or that is not common stock, is listed but left out of the values; a trade reported by several filers is counted once.
Filing footnotes · 1
F1Shares automatically sold to cover tax withholding obligation from settlement of vested restricted stock units.
F1Shares automatically sold to cover tax withholding obligation from settlement of vested restricted stock units.
F2The price reported above reflects the weighted average price of the shares sold. The sale price ranged from $14.20 to $14.34 per share. Upon request from the SEC staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price within the range set forth in this Form 4.
F1Shares automatically sold to cover tax withholding obligation from settlement of vested restricted stock units.
F2The price reported above reflects the weighted average price of the shares sold. The sale price ranged from $14.22 to $14.34 per share. Upon request from the SEC staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price within the range set forth in this Form 4.
F1Shares automatically sold to cover tax withholding obligation from settlement of vested restricted stock units.
F2The price reported above reflects the weighted average price of the shares sold. The sale price ranged from $14.27 to $14.34 per share. Upon request from the SEC staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price within the range set forth in this Form 4.
F1Shares automatically sold to cover tax withholding obligation from settlement of vested restricted stock units.
F2The price reported above reflects the weighted average price of the shares sold. The sale price ranged from $14.22 to $14.34 per share. Upon request from the SEC staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price within the range set forth in this Form 4.
F1Reflects 2,857,490 shares of Common Stock beneficially owned by the Reporting Person immediately prior to the reported transaction, less the 10 shares sold.
F1Reflects 2,857,500 shares of Common Stock beneficially owned by the Reporting Person immediately prior to the reported transaction, less the 10 shares sold.
F1Shares automatically sold to cover tax withholding obligation from settlement of vested restricted stock units.
F2The price reported above reflects the weighted average price of the shares sold. The sale price ranged from $18.91 to $19.30 per share. Upon request from the SEC staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price within the range set forth in this Form 4.
F1Shares automatically sold to cover tax withholding obligation from settlement of vested restricted stock units.
F2The price reported above reflects the weighted average price of the shares sold. The sale price ranged from $18.91 to $19.30 per share. Upon request from the SEC staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price within the range set forth in this Form 4.
F3Includes 1,000 shares acquired on May 18, 2026 under the Issuer's 2021 Employee Stock Purchase Plan.
F1Shares automatically sold to cover tax withholding obligation from settlement of vested restricted stock units.
F2The price reported above reflects the weighted average price of the shares sold. The sale price ranged from $18.91 to $19.30 per share. Upon request from the SEC staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price within the range set forth in this Form 4.
F3Includes 188 shares acquired on May 18, 2026 under the Issuer's 2021 Employee Stock Purchase Plan.
F1Shares automatically sold to cover tax withholding obligation from settlement of vested restricted stock units.
F2The price reported above reflects the weighted average price of the shares sold. The sale price ranged from $18.91 to $19.15 per share. Upon request from the SEC staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price within the range set forth in this Form 4.
F1These shares are directly held by ARCH Venture Fund XIII, L.P. ("ARCH XIII"). ARCH Venture Partners XIII, L.P. ("AVP XIII LP") is the general partner of ARCH XIII. ARCH Venture Partners XIII, LLC ("AVP XIII LLC") is the general partner of AVP XIII LP. Keith Crandell, Robert Nelsen, Kristina Burow, Paul Berns and Steven Gillis are members of the investment committee of AVP XIII LLC (the "AVP XIII LLC Committee Members"). Each of AVP XIII LP and AVP XIII LLC may be deemed to beneficially own the shares held by ARCH XIII, and each of the AVP XIII LLC Committee Members may be deemed to share the power to direct the disposition and vote of the shares held by ARCH XIII. Each of AVP XIII LP, AVP XIII LLC and the AVP XIII LLC Committee Members disclaims beneficial ownership except to the extent of their pecuniary interest therein, if any.
F2These shares are directly held by ARCH Venture Fund IX, L.P. ("ARCH IX"). ARCH Venture Partners IX, L.P. ("GPLP"), as the sole general partner of ARCH IX, may be deemed to beneficially own the shares held by ARCH IX. ARCH Venture Partners IX, LLC ("GPLLC"), as the sole general partner of GPLP, may be deemed to beneficially own the shares held by ARCH IX. As managing directors of GPLLC, each of Keith Crandell, Robert Nelsen and Clinton Bybee (the "ARCH Managing Directors"), may be deemed to beneficially own the shares held by ARCH IX. Each of GPLP, GPLLC and the ARCH Managing Directors disclaims beneficial ownership of the securities reported herein, except to the extent of their pecuniary interest therein, if any.
F3These shares are directly held by ARCH Venture Fund IX Overage, L.P. ("ARCH Overage"). ARCH Venture Partners IX Overage, L.P. ("Overage GPLP"), as the sole general partner of ARCH Overage, may be deemed to beneficially own the shares held by ARCH Overage. GPLLC, as the sole general partner of Overage GPLP, may be deemed to beneficially own the shares held by ARCH Overage. As managing directors of GPLLC, each of the ARCH Managing Directors may be deemed to beneficially own the shares held by ARCH Overage. Each of Overage GPLP, GPLLC and the ARCH Managing Directors disclaims beneficial ownership of the securities reported herein, except to the extent of their pecuniary interest therein, if any.
F1These shares are directly held by ARCH Venture Fund XIII, L.P. ("ARCH XIII"). ARCH Venture Partners XIII, L.P. ("AVP XIII LP") is the general partner of ARCH XIII. ARCH Venture Partners XIII, LLC ("AVP XIII LLC") is the general partner of AVP XIII LP. Keith Crandell, Robert Nelsen, Kristina Burow, Paul Berns and Steven Gillis are members of the investment committee of AVP XIII LLC (the "AVP XIII LLC Committee Members"). Each of AVP XIII LP and AVP XIII LLC may be deemed to beneficially own the shares held by ARCH XIII, and each of the AVP XIII LLC Committee Members may be deemed to share the power to direct the disposition and vote of the shares held by ARCH XIII. Each of AVP XIII LP, AVP XIII LLC and the AVP XIII LLC Committee Members disclaims beneficial ownership except to the extent of their pecuniary interest therein, if any.
F2These shares are directly held by ARCH Venture Fund IX, L.P. ("ARCH IX"). ARCH Venture Partners IX, L.P. ("GPLP"), as the sole general partner of ARCH IX, may be deemed to beneficially own the shares held by ARCH IX. ARCH Venture Partners IX, LLC ("GPLLC"), as the sole general partner of GPLP, may be deemed to beneficially own the shares held by ARCH IX. As managing directors of GPLLC, each of Keith Crandell, Robert Nelsen and Clinton Bybee (the "ARCH Managing Directors"), may be deemed to beneficially own the shares held by ARCH IX. Each of GPLP, GPLLC and the ARCH Managing Directors disclaims beneficial ownership of the securities reported herein, except to the extent of their pecuniary interest therein, if any.
F3These shares are directly held by ARCH Venture Fund IX Overage, L.P. ("ARCH Overage"). ARCH Venture Partners IX Overage, L.P. ("Overage GPLP"), as the sole general partner of ARCH Overage, may be deemed to beneficially own the shares held by ARCH Overage. GPLLC, as the sole general partner of Overage GPLP, may be deemed to beneficially own the shares held by ARCH Overage. As managing directors of GPLLC, each of the ARCH Managing Directors may be deemed to beneficially own the shares held by ARCH Overage. Each of Overage GPLP, GPLLC and the ARCH Managing Directors disclaims beneficial ownership of the securities reported herein, except to the extent of their pecuniary interest therein, if any.
F1Shares automatically sold to cover tax withholding obligation from settlement of performance-based vested restricted stock units.
F2The price reported above reflects the weighted average price of the shares sold. The sale price ranged from $23.3939 to $24.6305 per share. Upon request from the SEC staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price within the range set forth in this Form 4.
F1Shares automatically sold to cover tax withholding obligation from settlement of performance-based vested restricted stock units.
F2The price reported above reflects the weighted average price of the shares sold. The sale price ranged from $23.3939 to $24.7850 per share. Upon request from the SEC staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price within the range set forth in this Form 4.
F1Shares automatically sold to cover tax withholding obligation from settlement of performance-based vested restricted stock units.
F2The price reported above reflects the weighted average price of the shares sold. The sale price ranged from $23.3939 to $24.7850 per share. Upon request from the SEC staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price within the range set forth in this Form 4.
F1Represents restricted stock units granted under the Issuer's 2021 Equity Incentive Plan. 12.5% of the total number of restricted stock units will vest on August 9, 2026, and thereafter an additional 1/16th of the total number of restricted stock units will vest quarterly thereafter, subject to the reporting person providing service through the applicable vesting date.
F2Shares automatically sold to cover tax withholding obligation from settlement of vested restricted stock units.
F1Pursuant to performance-based restricted stock units granted to the reporting person on February 9, 2024, 4,000 shares were issued on the Transaction Date upon the achievement of certain performance criteria certified by the compensation committee of the Issuer's board of directors on the Transaction Date.
F2Includes 390 shares acquired on November 18, 2025 under the Issuer's 2021 Employee Stock Purchase Plan.
F3Shares automatically sold to cover tax withholding obligation from settlement of vested restricted stock units.
F4Twelve and one-half percent (12.5%) of the total number of shares of Common Stock subject to the option will be vested and exercisable on the date that is six (6) months after February 9, 2026 (the "Vesting Commencement Date") and thereafter, an additional one fortyeighth (1/48th) of the shares will become vested and exercisable monthly on the same day as the Vesting Commencement Date (or, if there is no such corresponding day for a given month, on the last day of such month), until the option has become vested and exercisable with respect to one hundred percent (100%) of the shares, subject to the Reporting Person providing service to the Issuer through each applicable vesting date.
F1Pursuant to performance-based restricted stock units granted to the reporting person on February 9, 2024, 4,000 shares were issued on the Transaction Date upon the achievement of certain performance criteria certified by the compensation committee of the Issuer's board of directors on the Transaction Date.
F2Includes 390 shares acquired on November 18, 2025 under the Issuer's 2021 Employee Stock Purchase Plan.
F3Shares automatically sold to cover tax withholding obligation from settlement of vested restricted stock units.
F4Twelve and one-half percent (12.5%) of the total number of shares of Common Stock subject to the option will be vested and exercisable on the date that is six (6) months after February 9, 2026 (the "Vesting Commencement Date") and thereafter, an additional one fortyeighth (1/48th) of the shares will become vested and exercisable monthly on the same day as the Vesting Commencement Date (or, if there is no such corresponding day for a given month, on the last day of such month), until the option has become vested and exercisable with respect to one hundred percent (100%) of the shares, subject to the Reporting Person providing service to the Issuer through each applicable vesting date.
F1Pursuant to performance-based restricted stock units granted to the reporting person on February 9, 2024, 20,000 shares were issued on the Transaction Date upon the achievement of certain performance criteria certified by the compensation committee of the Issuer's board of directors on the Transaction Date.
F2Shares automatically sold to cover tax withholding obligation from settlement of vested restricted stock units.
F3Twelve and one-half percent (12.5%) of the total number of shares of Common Stock subject to the option will be vested and exercisable on the date that is six (6) months after February 9, 2026 (the "Vesting Commencement Date") and thereafter, an additional one forty-eighth (1/48th) of the shares will become vested and exercisable monthly on the same day as the Vesting Commencement Date (or, if there is no such corresponding day for a given month, on the last day of such month), until the option has become vested and exercisable with respect to one hundred percent (100%) of the shares, subject to the Reporting Person providing service to the Issuer through each applicable vesting date.
F1The price reported above reflects the weighted average price of the shares sold. The sale price ranged from $38.6643 to $38.6751 per share. Upon request from the SEC staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price within the range set forth in this Form 4.
F1Shares automatically sold to cover tax withholding obligation from settlement of vested restricted stock units.
F2The price reported above reflects the weighted average price of the shares sold. The sale price ranged from $16.08 to $16.11 per share. Upon request from the SEC staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price within the range set forth in this Form 4.
